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Mental Disorders
For this discussion:
?Using one of the research methods discussed in the text (Microdialysis), locate and read a recent, full-text article from the Capella Library that utilizes biological research in the study of a particular disorder or behavior (Drug Abuse / Cocaine Drug Addict). Choose a disorder or behavior you will most likely work with in your particular area of specialization (Clinical Psychology). The study should utilize one or more of the research techniques of behavioral genetics (such as twin studies, adoption studies, targeted mutations, or psychophysiological techniques not related to genetics).
?Summarize the article, and outline the problem and the hypotheses of the study. Which research techniques were used?
?Analyze and explain how these techniques were helpful in answering the research questions.
?Cite and reference your article using APA formatting.
Genetics of Dopamine and its Contribution to Cocaine Addiction by Haile, Colin N; Kosten, Thomas R; Kosten, Therese A. Behavior Genetics, ISSN 0001-8244, 01/2007, Volume 37, Issue 1, pp. 119 – 145
Abstract (summary)
Cocaine addiction is a major health and social problem for which there are presently no effective pharmacotherapies. Many of the most promising medications target dopamine based on the large literature that supports its role in addiction. Recent studies show that genetic factors are also important. Rodent models and gene knock-out technology have helped elucidate the involvement of specific genes in the function of the dopamine reward system and intracellular cascades that lead to neuronal changes in this system. Human epidemiological, linkage, and association studies have identified allelic variants (polymorphisms) that give rise to altered metabolism of dopamine and its functional consequences. Individuals with these polymorphisms respond differently to psychostimulants and possibly to pharmacotherapies. Here we review the literature on genetic variations that affect dopamine neurotransmission, responses to psychostimulants and potential treatments for cocaine addiction. Behavioral responses to psychostimulants in animals with different or modified genetics in dopamine signaling are discussed. We also review polymorphisms in humans that affect dopaminergic neurotransmission and alter the subjective effects of psychostimulants. Pharmacotherapies may have increased efficacy when targeted to individuals possessing specific genetic polymophisms in dopamine’s metabolic and intracellular messenger systems.
Indexing (details)
Title Genetics of Dopamine and its Contribution to Cocaine Addiction
Author Haile, Colin N; Kosten, Thomas R; Kosten, Therese A
Publication title Behavior Genetics
Volume 37
Issue 1
Pages 119-45
Number of pages 27
Publication year 2007
Publication date Jan 2007 Year 2007
Publisher Springer Science & Business Media
Place of publication New York
Country of publication Netherlands
Journal subject Medical Sciences, Psychology, Biology, Biology?Genetics
ISSN 00018244
Source type Scholarly Journals
Language of publication English
DOI 10.1007/s10519-006-9115-2
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