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Please use scientific research papers and reviews (pubmed.com) as primary references. Citation style must be Cell.
The question is:
Because of the critical roles of TLRs (toll-like receptors) in both innate and adaptive immunity, defects in TLR-mediated signaling are responsible for a number of human immunodeficiencies. Choose ONE TLR which, because of aberrant signalling causes such a disease. Your answer should include the following:
a) description of the physical properties of the TLR
b) a description of the normal function of the TLR (in both innate and adaptive immunity if applicable)
c) a description of the normal signaling pathways through which this TLR signals (use a diagram to support your answer)
d) a description of the mutation/polymorphism/defect that impairs signalling pathways through which this TLR signals (Note: the mutation/polymorphism/defect does not have to be in the TLR itself, but may be in the signalling molecule that is part of the TLR-signalling pathway)
e) a description of how the resulting impaired signalling causes the disease
f) a description of the disease
g) a description of the available treatments for this disease (if none exists, make a statement to that effect)
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