Pharmacodynamics: Explain the differences between affinity, efficacy, and potency. Explain the differences among drugs that are agonists, partial agonists, and antagonists. List the four primary families of receptors and how they function in response to many drugs and physiologic processes. Explain the concept of therapeutic index and its relationship to factors that effect the desired therapeutic dose. Define ED50 and LD50. Consider the following: Here are the data for two pain relieving drugs used to manage severe postoperative pain. Both are able to relieve pain completely, provided the proper dose is given.o Drug A: ED50 = 10 mg // LD50 = 500mgo Drug B : ED50 = 1 mg // LD50 = 20mg? Which drug is most efficacious?? Which drug is the most potent?? Which has the greatest therapeutic index?? Which is safer to administer?? Which causes the fewest side effects?
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