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1-What is a prospective study of a representative birth cohort?
2-Is the case definition for periodontitis appropriate?
3-Is the method of measuring smoking exposure appropriate?
4-What is logistic regression analysis?
5-Are the risk factors for periodontitis in Table 1 and 2 surprising? What are the implications of your answer for the quality of the study?
6-The authors argue from table 2 that people who gave up smoking after age 26 had similar periodontal disease experience as those who had never smoked. How do they reach this conclusion in Table 2?
7-The authors concluded from Table 2 that these data are the "first epidemiological confirmation that smoking cessation after the mid-20 may be associated with an improvement in the periodontal tissues which is detectable by the early 30s". Table 3 provides evidence that contradicts that conclusion. What is the evidence?
8-What else accounts for the lack of statistical difference in the prevalence of periodontitis amongst smokers who gave up after 26 years and non-smokers?
9-Based on this study, what would your recommendation be, regarding smoking cessation advise in dental practice?
10-As well as providing longitudinal evidence of cause and effect, birth-cohort studies challenge prevailing modeles of disease aetiology that emphasise adult lifestyle factors for adult diseases. How do they challenge these models? What is the name for this approach in chronic disea epidemiology?
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